Efficiency of combined detection of CAR,PCT and TNF-α levels in diagnosis of anastomotic fistula in postoperative patients with colorectal cancer
Objective:To analyze efficiency of combined detection of C-reactive protein/serum albumin (CAR),procalcitonin (PCT) and tumor necrosis factor-α (TNF-α) levels in diagnosis of anastomotic fistula in postoperative patients with colorectal cancer. Methods:The clinical data of 303 patients undergoing laparoscopic radical resection of colorectal cancer in the hospital from 2020 to 2022 were retrospectively analyzed. These patients were divided into occurrence group (n=41) and non-occurrence group (n=262) according to whether anastomotic fistula occurred within 10 days after the surgery. The levels of CAR,PCT and TNF-α3 days after the surgery were compared between the two groups. The receiver operating characteristic curve (ROC) was drawn to analyze the efficiencies of single and combined detection of CAR,PCT and TNF-α levels in the diagnosis of anastomotic fistula in the postoperative patients with colorectal cancer. Results:3 days after the surgery,the levels of CAR,PCT and TNF-α in the occurrence group were higher than those in the non-occurrence group,and the differences were statistically significant (P<0.05). The ROC curve analysis showed that the areas under the curve of single and combined detection of CAR,PCT and TNF-α levels in the diagnosis of anastomotic fistula in the patients with colorectal cancer at 3 days after the surgery were 0.810,0.790,0.804 and 0.947,separately,all of which had certain diagnostic efficiency,and the efficiency of combined detection in the diagnosis of anastomotic fistula in the postoperative patients with colorectal cancer was higher than that of single detection. Conclusions:The efficiency of combined detection of CAR,PCT and TNF-α levels in the diagnosis of anastomotic fistula in the postoperative patients with colorectal cancer is higher than that of single detection of the three.
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