Predictive value of combined detection of serum galectin-1 and interleukin-12 levels for placental abruption in patients with severe preeclampsia
Objective:To analyze predictive value of serum galectin-1 (Gal-1) and interleukin-12 (IL-12) levels for placental abruption in patients with severe preeclampsia (SPE). Methods:The clinical data of 82 patients with SPE admitted to this hospital from February 2021 to December 2023 were retrospectively analyzed and they were set as the study group. 82 pregnant women who underwent normal pregnancy examination during the same period were selected as the control group. According to whether placental abruption occurred before delivery,the SPE patients were divided into patients with and without placental abruption. The levels of serum Gal-1 and IL-12 were compared between the two groups and the patients with and without SPE. The correlations among the serum Gal-1 and IL-12 levels and placental abruption in the SPE patients were analyzed using Pearson correlation analysis. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of single and combined detection of serum Gal-1 and IL-12 levels for placental abruption in the SPE patients. Results:The levels of serum Gal-1 and IL-12 in the study group were higher than those in the control group,and the differences were statistically significant (P<0.05). The levels of serum Gal-1 and IL-12 in the patients with placental abruption were higher than those in the patients without placental abruption,and the differences were statistically significant (P<0.05). The Pearson correlation analysis showed that the serum Gal-1 and IL-12 levels were positively correlated with placental abruption in the SPE patients (r>0,P<0.05). The ROC curve analysis showed that the areas under the curve of single and combined detection of serum Gal-1 and IL-12 levels in the prediction of placental abruption in the SPE patients were 0.811,0.896 and 0.931,separately,and the combined detection had the highest predictive value. Conclusions:The predictive value of combined detection of serum Gal-1 and IL-12 levels for placental abruption in the SPE patients is higher than that of single detection.
Severe preeclampsiaGalectin-1Interleukin-12Placental abruptionPredictive value
万方数据
维普
