Efficiency of high-risk human papillomavirus detection combined with thin-prep cytology test in diagnosis of cervical intraepithelial neoplasia
Objective:To analyze efficiency of high-risk human papillomavirus (HR-HPV) detection combined with thin-prep cytology test (TCT) in diagnosis of cervical intraepithelial neoplasia (CIN). Methods:The clinical data of 148 patients with suspected CIN admitted to this hospital from April 2021 to April 2023 were retrospectively analyzed. TCT,HR-HPV detection and pathological examination were performed. Using the results of pathological examination as the gold standard,the efficienciy of single and combined detection of HR-HPV,TCT in the diagnosis of CIN were compared. Results:Among the 148 patients with suspected CIN,pathological examination diagnosis was positive in 95 cases and negative in 53 cases. TCT diagnosis was positive in 88 cases and negative in 60 cases. HR-HPV test was positive in 78 cases and negative in 70 cases. HR-HPV detection combined with TCT diagnosed 93 positive cases and 55 negative cases. The sensitivity,accuracy and negative predictive value of HR-HPV detection combined with TCT in the diagnosis of CIN were higher than those of two individual single detection,the missed diagnosis rate was lower than that of two individual single detection,and the differences were statistically significant (P<0.05). Conclusions:The efficiency of HR-HPV detection combined with TCT in the diagnosis of CIN is higher than that of each single detection.
Cervical intraepithelial neoplasiaThin-prep cytology testHigh-risk human papillomavirusDiagnosis
万方数据
维普
