Depression is mainly about persistent depression,decreased interest or loss of happiness,self-blame,reduced speech activity,insomnia and reduced appetite,and even physical and mental symptoms such as suicide,as well as reduced cognitive functions such as lack of concentration,slow thinking,and decreased information processing and execution ability.Clinical drug therapy has become the main treatment for depression.This paper discusses the comparative study of fluoxidine hydrochloride and Mongolian Medicine Areca Thirteen Pill in the treatment of depression.