Research on the Mechanism of Yupingfeng Powder in Treating Recurrent Respiratory Tract Infection in Children Based on Network Pharmacology and Molecular Docking Technology
Objective:To explore the mechanism of Yupingfeng Powder in the treatment of recurrent respiratory tract infections(RRTIs)in children.Methods:TCMSP database was used to retrieve the active ingredients and related targets of Yupingfeng Powder,and supplement through the SwissTargetPrediction.The RRTIs'disease related targets were searched through the GeneCards,DrugBank,Disgene,PharmaGkb and OMIM databases.Built a"disease-Chinese herb-ingredients-targets"relational network by Cytoscape software,and the protein-protein interaction was constructed with the STRING platform.Conducted GO and KEGG enrichment analysis on intersecting targets.Based on the Discovery studio software,the main target proteins are molecularly docked with main active compounds.Results:44 active ingredients and 465 targets were collected from Yupingfeng Powder;Among them,there are 260 targets related to RRTIs,which has core targets being TP53 and SRC,involving signal pathways such as PI3K-Akt,TNF,IL-17 and CLR.Molecular docking indicates that the main active compounds have good binding power with the main targets of diseases.Conclusion:Yupingfeng Powder can enhance immune response levels and control inflammatory response in RRTIs through multiple components,pathways and targets.
YupingfengRecurrent respiratory tract infections in childrennetwork pharmacologymolecular docking
NETL
NSTL
万方数据
