Objective:To observe the clinical effect and mechanism of glycyrrhix Xiexin Decoction combined with external treatment on spleen deficiency damp-heat type recurrent oral ulcer.Methods:A prospective randomized controlled clinical trial was conducted on 62 patients with recurrent oral ulcers who met the inclusion criteria and visited Professor Niu Xingdong's outpatient clinic at Inner Mongolia Autonomous Region Traditional Chinese Medicine Hospital from June 2018 to February 2023.31 cases each in the treatment group and 31 cases in the control group.The control group was given compound vitamin tablets and Xidi iodine tablets;The treatment group was additionally treated with Gancao Xiexin Tang and combined with external treatment for 14 days.Compare the VAS score,Pittsburgh Sleep Scale score,diarrhea severity score,and serum inflammatory factor indicators(IL-2,IL-6,TNF)of two groups of patients before and after treatment-a)Changes in treatment outcomes and treatment outcomes.The experimental data was entered using SPSS 22.0 professional statistical software for statistical analysis.No adverse reactions were found during the experiment.Results:In terms of the total effective rate,the total effective rate of the treatment group was 93.5％,which was significantly higher than that of the control group(74.2％),the difference was significant(P＜0.05).VAS scores of oral ulcer in 2 groups were decreased and pain degree was improved after treatment,with statistical difference before and after treatment(P＜0.05).However,a comparison between the two groups found that the pain improvement in the treatment group was significantly better than the control group.After treatment,it was found that the symptoms of insomnia and diarrhea in the treatment group were significantly improved,and the difference was statistically significant(P＜0.05).No statistical difference was observed in the control group before and after treatment.Statistical analysis was performed before treatment in both groups,and the statistical results showed that there was no statistical difference between the two groups before treatment(P＞0.05).There were statistical differences between the two groups after treatment and before treatment,indicating that the levels of IL-2,IL-6 and TNF-α in the two groups were reduced to a certain extent after treatment.However,there was a statistical difference in the degree of reduction between the two groups after treatment(P＜0.05),indicating that the treatment group was better than the control group in reducing inflammatory indicators in patients with recurrent oral ulcer.Conclusion:Glycyrrhiza Xiexin Decoction combined with external treatment is effective in the treatment of spleen deficiency damp-heat type recurrent oral ulcer,which can effectively improve the main symptoms of pain,insomnia and diarrhea,shorten the course of the disease,improve immune function and reduce the recurrence rate.
Recurrent oral ulcerglycyrrhiza Xiexin Decoctiondampness-heat syndrome of spleen deficiency
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