Objective:Based on the method of network pharmacology,to screen the active ingredients of nutmeg,predict its potential anti-tumor targets and screen the related pathways of potential anti-tumor targets,and explore its anti-tumor mechanism.Methods:By consulting a large number of domestic and foreign literatures,sorting out and obtaining the active ingredients of nutmeg,using a variety of databases to predict the relevant targets of the ingredients,and mapping with tumor targets,the potential anti-tumor targets of the active ingredients were obtained.The"compound-gene"network map was constructed with Cystoscope 3.6.1 software to screen key compounds and key targets.Finally,pathway enrichment analysis was performed.Results:A total of 19 active ingredients were screened from nutmeg,and 70 high-frequency targets and 13 signaling pathways related to tumor were screened through network modeling.The results of enrichment analysis showed that these pathways may be the basis for the anti-tumor activity of nutmeg.Conclusion:Through this virtual network screening,nutmeg exerts its anti-tumor effect through multi-component,multi-target and multi-pathway anti-tumor mode,which can provide new ideas and clues for further research on the anti-tumor mechanism of nutmeg.
NETL
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万方数据
