Research on the mechanism of Mongolian medicine Zhizisanwei Powder in preventing and treating diabetes based on Internet pharmacology
Objective:To predict the potential active ingredients and the mechanism of treating diabetes with Mongolian medicine Zhizi Sanwei Powder using network pharmacology method.Methods:Active ingredients of Mongolian medicine Zhizi Sanwei Powder were gathered from TCMSP,the potential targets of Mongolian medicine Zhizi Sanwei Powder were searched and collected from Pubchem and Swiss Target Prediction databases;GeneCards、TTD and OMIM databases were used for data integration and deduplication to obtain the final diabetes mellitus targets.Use DAVID 6.8 for GO annotation and KEGG pathway enrichment analysis of potential targets,and use Cytoscape 3.6.0 software to construct the"active ingredient-target-pathway"network.Use Discovery Studio software for molecular docking of core targets and their corresponding components.Results:31 active ingredients were screened from the Mongolian medicine Zhizi Sanwei Powder,it could treat diabetes by intervening 203 targets and adjusting 7 pathways such as PI3K-Akt signaling pathway,Calcium signaling pathway、cAMP signaling pathway and Insulin signaling pathway.The results of molecular docking showed that the main active components had good binding activity with the core target protein.Conclusion:Mongolian medicine Zhizi Sanwei Powder could treat diabetes mellitus via multiple ingredients,targets and pathways.
Mongolian medicine Zhizi Sanwei PowderDiabetes mellitusNetwork pharmacologyMechanism of action
万方数据
维普
