The Chinese Experts'Consensus on the Clinical Application of L-carnitine in andrological diseases(Appendix:Method for detecting carnitine in seminal plasma or serum)
Objective L-carnitine plays a crucial role in sperm maturation and energy metabolism,exerting multiple functions such as improving sperm quality,maintaining sperm DNA integrity,and facilitating sperm-egg binding.Guidelines and consensus,including the Expert Consensus on the Clinical Application of L-carnitine in Male Infertility(2014 Edition)and the Guidelines for the Diagnosis and Treatment of Male Infertility(2022 Edition),have clarified the clinical value of L-carnitine in the treatment of male infertility and provided recommendations on its standardized application.With further study on the physiological effects of L-carnitine,it has been found that L-carnitine exerts multifaceted effects such as improving mitochondrial function and energy metabolism,possessing the ability of anti-oxidation and anti-apoptosis,promoting nerve regeneration and nutrition and neurotransmitter regulation,as well as facilitating gene expression regulation.Meanwhile,several clinical studies have demonstrated that in addition to male infertility,L-carnitine also plays a role in the treatment of many other andrological diseases,including Peyronie's disease,late-onset hypogonadism,and erectile dysfunction.This consensus is hereby developed to further clarify the clinical application of L-carnitine in various andrological diseases,giving detailed information on the distribution of L-carnitine in the human body,its basic physiological effects as well as its pharmacological effects,clinical research progress,and standardized medication in various andrological diseases to ultimately provide guidance and reference for clinical medication.
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