Exploring the causal relationship between obstructive sleep apnea and male infertility using Mendelian randomization
Objective To explore the relationship between obstructive sleep apnea(OSA)and male infertility(MI)and evaluate the potential causal effect of OSA on MI through a two-sample Mendelian randomization(MR)analysis.Methods Two-sample MR analysis was conducted using genome-wide association study(GWAS)data,including 25 062 cases of SA,172 050 cases of snoring,and 313 372 controls,as well as summary data extracted from FinnGen for male infertility(1 271 cases and 119 297 controls).The primary analytical method was the inverse variance-weighted(IVW)approach,supplemented by MR-Egger regression,weighted median,simple mode,and weighted mode to provide additional evidence corroborating the IVW results.Tests for horizontal pleiotropy and heterogeneity were performed to ensure result stability.Results There was no substantial evidence supporting an association between OSA and MI incidence using the IVW method(OR=1.617,95％CI:0.823-3.177,P=0.163).The result of MR-Egger,weighted median,simple mode,and weighted mode methods were consistent with the results of the IVW method.Conclusion The large MR analysis indicated that obstructive sleep apnea may not be causally associated with a risk of male infertility.
sleep apnea,obstructiveinfertility,maleMendelian randomization analysisGenome-wide association study
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