三才封髓膏治疗肾虚湿热证早泄临床疗效观察
Clinical observation of Sancaifengsui ointment in the treatment of premature ejaculation of kidney deficiency dampness-heat type
符方智 1杨扬 1邹博 1龙衍 1周青1
作者信息
- 1. 湖南中医药大学第一附属医院男性病外科杂病一科(湖南长沙 410021)
- 折叠
摘要
目的 探讨三才封髓膏治疗肾虚湿热证早泄的临床疗效和安全性.方法 选取2021年10月至2022年3月湖南中医药大学第一附属医院男科门诊诊治的140例早泄患者为研究对象,采用随机分组将其分为中医组和对照组,每组各70例患者.中医组给予三才封髓膏治疗,对照组给予盐酸达泊西汀片治疗,4周为1个疗程,共计观察8周.通过比较2组患者治疗前、治疗4周及8周的阴道内射精潜伏期(IELT)、早泄诊断量表(PEDT)、中医证候积分、临床总体印象变化(CGIC),并记录不良反应,评估药物临床疗效和安全性.结果 组内比较IELT、PEDT评分、中医证候评分和CGIC,统计结果显示两组患者在治疗后均出现不同程度改善(P＜0.05),其中中医组中医证候评分治疗8周疗效优于治疗4周.组间比较结果显示,中医组和对照组IELT均为180(120,180)s,两组间无统计学差异;中医组PEDT评分为8.00(5.00,9.00)分,与对照组7.00(5.00,10.00)分无统计学差异;中医组中医证候评分为6.00(5.00,8.00)分,低于对照组12.00(7.00,14.00);中医组总有效率为90.0％,高于对照组77.1％(P＜0.05);对照组出现9例不良反应事件,高于中医组0例(P＜0.05).结论 三才封髓膏治疗肾虚湿热证早泄临床疗效良好,可以改善射精控精能力和紧张焦虑情绪,同时能够改善患者肾虚湿热证型相关中医症状,提高患者生活质量,且药物安全性良好.
Abstract
Objective To investigate the clinical efficacy and safety of Sancaifengsui ointment in the treatment of premature ejaculation with kidney deficiency and dampness-heat.Methods A total of 140 patients with premature ejaculation who were treated in the andrology clinic of the first affiliated hospital of Hunan university of chinese medicine from October 2021 to March 2022 were recruited as the research objects.The patients were randomly divided into two group including the traditional Chinese medicine group(70 patients)and the control group(70 patients).The patients in the traditional Chinese medicine group were treated with Sancaifengsui herbal paste,and the patients in the control group were treated with dapoxetine hydrochloride tablets,4 weeks as a course of treatment and the patients were observed for 8 weeks.The clinical efficacy and safety of the drugs were evaluated by comparing the intravaginal ejaculation latency(IELT),Premature ejaculation diagnostic scale(PEDT),TCM syndrome score,clinical global impression of change(CGIC)and recorded adverse reactions before treatment,4 weeks and 8 weeks after treatment.Results Analysis of the results of IELT,PEDT scores,traditional Chinese medicine syndrome scores,and CGIC within the group showed that the patients in two groups were all improved to varying degree after treatment(P＜0.05).Among them,the traditional Chinese medicine syndrome score in the traditional chinese medicine group showed better efficacy after 8 weeks of treatment than after 4 weeks of treatment.Analysis of inter group results revealed that the IELT of both the traditional chinese medicine group and the control group was 180(120,180)seconds,and there was no significant difference between the two groups;The PEDT score of the traditional chinese medicine group was 8.00 points,which was not significantly different from that of the control group(7.00 points);The TCM syndrome score in the TCM group was 6.00 points,which was lower than the control group(12.00 points);The total effective rate of the traditional chinese medicine group was 90.0％,which was higher than that of the control group(77.1％,P＜0.05);There were 9 adverse reaction events in the control group,which was higher than that in the traditional chinese medicine group(0 cases,P＜0.05).Conclusions Sancaifengsui herbal paste has good clinical efficacy in the treatment of premature ejaculation with kidney deficiency and damp heat.It can significantly improve the ability of ejaculation control and anxiety,improve the TCM symptoms related to kidney deficiency and damp heat syndrome,and improve the quality of life of patients.
关键词
三才封髓膏/肾虚湿热证/早泄Key words
Sancaifengsui ointment/kidney deficiency dampness-heat type/premature ejaculation引用本文复制引用
基金项目
湖南省性与生殖健康中医临床医学研究中心项目(湘科计2020SK4014)
湖南省一类中医重点专科项目(湘中医药函20234号)
湖南中医药大学"一方"研究生创新课题(2022YF09)
出版年
2024
NETL
NSTL
万方数据