Objective To investigate the effectiveness,safety and economy of Qianliexin capsule in the treatment of chronic prostatitis using multi-center and real world research method for providing the guidance for clinical application.Methods A total of 3 399 patients with chronic prostatitis were enrolled from 22 centers across the country.The patients received Qianliexin capsule alone or in addition to their conventional treatment.NIH-CPSI scores were observed and recorded before and after treatment,and changes in total response rate,score halving rate,symptom disappearance rate and single symptom score were analyzed.Adverse reactions were observed and abnormal rate of liver and kidney function(ALT/AST/Cr),as well as cost-effectiveness ratio and incremental cost-effectiveness ratio during treatment cycle were recorded.Results After treatment,the total NIH-CPSI score decreased compared with that before treatment,and the total effective rate was 89.79%,the difference was statistically significant(P<0.001).The overall halving rate of pain or discomfort symptom score was 76.21%,and the overall halving rate of urination symptom score was 78.26%.The overall disappearance rate of pain or discomfort symptom score was 23.36%,and the overall disappearance rate of urination symptom score was21.77%.The incidence of adverse reactions was 0.47%,and the frequency was rare.No serious adverse reactions were found.In the economic evaluation,the cost-effectiveness ratio of Qianliexin capsule used alone(3.42 yuan/%)was the smallest.Conclusion Qianliexin capsule can significantly improve the pain and discomfort symptoms and urination symptoms of chronic prostatitis patients in real medical scenes,with good safety and high economy.
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