"脑-肠-睾丸"轴的内涵及其在男性生殖疾病中的运用展望
The connotation of the"brain-gut-testis"axis and its application prospects in male reproductive diseases
邹和德 1赵家有 1陈文康 1刘寒飞 2曹芮 2张鹤坤 2张雅鹏1
作者信息
- 1. 中国中医科学院研究生院(北京 100700)
- 2. 河北中医药大学(河北 石家庄 050091)
- 折叠
摘要
肾为先天之本,藏精生髓,主生殖.脑为髓海,由肾精所化,亦受后天脾胃化生之水谷精微充养.脾胃为后天之本,主受纳运化,化生水谷精微,大、小肠与之功能联系紧密.男性生殖疾病日益受到重视,受中医先后天关系启发,基于脑肠关系、肠睾关系等科学研究进展,认为大脑、胃肠、睾丸三者相互作用,共同维护男性生殖健康,凝练提出男性生殖的"脑-肠-睾丸"轴,具体有大脑通过神经内分泌等调节胃肠与睾丸功能,胃肠可通过肠道菌群、脑肠肽等影响大脑与睾丸功能,睾丸可通过雄激素等影响胃肠与大脑功能.大脑功能、胃肠功能与睾丸生殖功能相互作用,三者生理上相互协调,病理上相互影响,共同维持和影响男性生殖健康.
Abstract
The kidney is the innate foundation,storing essence and generating marrow,and is responsible for reproduction.The brain is a sea of marrow,which was transformed by kidney essence,and also nourished by water and grain essence derived from the spleen and stomach.The spleen and stomach are the foundation of postnatal development,mainly responsible for receiving,transporting,and transforming water and grain essence.The functions of the large and small intestine are closely related to them.Male reproductive diseases are increasingly receiving attention.Inspired by the innate and acquired relationship in traditional Chinese medicine,the relationship between the brain and intestines,as well as the relationship between intestines and testes,based on scientific research progress in traditional Chinese medicine,it is believed that the brain,intestines,and testes interact to jointly maintain male reproductive health.So,the"brain-gut-testis"axis of male reproduction is condensed and proposed.Specifically,the brain regulates gastrointestinal and testicular functions through neuroendocrine mechanisms,and the gastrointestinal tract can affect brain and testicular function through gut microbiota,brain gut peptides and other factors,while testicles can affect gastrointestinal and brain function through androgens and other factors.The interaction between brain function,gastrointestinal function,and testicular reproductive function is coordinated physiologically and affects pathologically,jointly maintaining and affecting male reproductive health.
关键词
"脑-肠-睾丸"轴/男性生殖疾病/肾/脑/脾胃Key words
"brain-gut-testis"axis/male reproductive diseases/kidney/brain/spleen and stomach引用本文复制引用
基金项目
国家自然科学基金面上项目(82274337)
首都卫生发展科研专项项目(首发2022-2-4271)
中国中医科学院科技创新工程(CI2023C018YL)
中国中医科学院科技创新工程(CI2021A02207)
中华中医药学会青年求实项目(2022-QNQSDEP-20)
出版年
2024
NETL
NSTL
万方数据