Research progress on the mechanism of single gene mutation during meiosis in non-obstructive azoospermia
Non-obstructive azoospermia(NOA)occupies a large proportion of male infertility,and NOA is difficult to be cured due to its unclear pathogenesis.At present,there is limited research on NOA genetic variation,and it is still inevitable for NOA patients to undergo testicular puncture biopsy in clinical diagnosis,which may cause unnecessary damage to the patients.An increasing reports on NOA suggest that single-gene mutations during meiosis is one of the important causes of NOA occurrence.In this article,we review and summarize the mechanisms of single-gene mutation in NOA meiosis for providing reference for the clinical treatment.
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