Application analysis of prostate cancer animal models based on data mining
Objective To summarise the characteristics of the prostatic cancer (PCa) animal model and to provide reference for the improvement of the PCa animal model.Methods We searched the relevant literature on PCa animal models in China national Knowledge infrastracture,Wanfang database,PubMed and WOS databases,summarized the types of experimental animals,gender,tumour cell lines and modelling methods,and set up a database for statistical analysis.Results A total of 300 papers were included,and the statistical analysis revealed that BALB/c male nude mice were preferred as PCa model animals.The modelling method is mostly subcutaneous abdominal cytosol transplantation;the cancer cell types are mostly PC-3 and DU145 of human origin;the number of inoculation is mostly 1 × 106 per animal;and the detection indexes mainly include apparent indexes of tumour tissues,histopathology,immunohistochemistry,and so on.Conclusion At present,there is a single type of PCa animal model,and the modelling method is mostly based on ectopic modelling,and there is a lack of models with a high degree of clinical compatibility.This study mined and analysed the journal literature on animal experiments of prostate cancer,with a view to providing reference and help for animal experiments of prostate cancer.
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