Research progress on the effect of freezing-thawing on human sperm mitochondria
Cryopreservation of human sperm is a crucial technology in the treatment of infertility and the preservation of male fertility.Mitochondria in sperm are crucial organelles for maintaining sperm vitality,and play an extremely important regulatory role in sperm capacitation,acrosome reaction,fertilization,and the maintenance of sperm vitality.However,freezing and thawing inevitably damages the structure and function of sperm mitochondria,subsequently determines the outcomes of assisted reproductive technologies.This paper provides a comprehensive review of the impact of cryopreservation and thawing on the biological functions,ultrastructure,membrane function,DNA,and protein of human sperm mitochondria.
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