首页|Damage on intestinal barrier function and microbial detoxification of deoxynivalenol:A review

Damage on intestinal barrier function and microbial detoxification of deoxynivalenol:A review

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  • 国家科技期刊平台
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Deoxynivalenol(DON)is a mycotoxin that is produced by various species of Fusarium and is ubiquitous in food and feed.At low concentrations,it can cause metabolic disorders in animals and humans and,at high concentrations,it can lead to pathological changes in the body.The impact of DON on human/animal health and animal productivity has thus attracted a great deal of attention around the world.DON causes severe damage to the intestine,including compromised intestinal barrier,mucosal damage,weakened immune function,and alterations in gut microbiota composition.These effects exacerbate intestinal infections and inflammation in livestock and poultry,posing adverse effects on overall health.Furthermore,research into biological methods for DON detoxification is a crucial avenue for future studies.This includes the utilization of adsorption,enzymatic degradation,and other biological approaches to mitigate DON's impact,offering new strategies for prevention and treatment of DON-induced diseases.Future research will focus on identifying highly efficient detoxifying microorganisms or enzymes to reduce DON levels in food and feed,thereby mitigating its risks to both animals and human health.

deoxynivalenol(DON)intestinal barrier functionmucus barrierimmune functionflora compositionbiological detoxification

Jia Chen、Xinran Zhang、Ziqi He、Dongwei Xiong、Miao Long

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Key Laboratory of Livestock Infectious Diseases,Ministry of Education/College of Animal Science and Veterinary Medicine,Shenyang Agricultural University,Shenyang 110866,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaBasic Scientific Research Project of Liaoning Provincial Department of Education,China

32273074319727463187253831772809LJKZ0632

2024

10.1016/j.jia.2023.11.038

农业科学学报(英文)
中国农业科学院农业信息研究所

农业科学学报(英文)

CSTPCD
影响因子：0.576
ISSN：2095-3119
年,卷(期)：2024.43(8)