首页|The Clausena Iansium genome provides new insights into alkaloid diversity and the evolution of the methyltransferase family

The Clausena Iansium genome provides new insights into alkaloid diversity and the evolution of the methyltransferase family

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The Clausena Iansium genome provides new insights into alkaloid diversity and the evolution of the methyltransferase family
Wampee (Clausena lansium) is an important evergreen fruit tree native to southern China that has a long history of use for medicinal purposes.Here,a chromosome-level genome of C.lansium was constructed with a genome size of 282.9 Mb and scaffold N50 of 30.75 Mb.The assembled genome contains 48.70％ repetitive elements and 24,381 protein-coding genes.Comparative genomic analysis showed that C.lansium diverged from Aurantioideae 15.91-24.95 million years ago.Additionally,some expansive and specific gene families related to methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity were also identified.Further analysis indicated that N-methyltransferase (NMT) is mainly involved in alkaloid biosynthesis and O-methyltransferase (OMT) participates in the regulation of coumarin accumulation in wampee.This suggested that wampee's richness in alkaloids and coumarins might be due to the gene expansions of NMT and OMT.The tandem repeat event was one of the major reasons for the NMT expansion.Hence,the reference genome of C.lansium will facilitate the identification of some useful medicinal compounds from wampee resources and reveal their biosynthetic pathways.

Clausena lansiumgenomeevolutionmethyltransferase activityalkaloid biosynthesiscoumarin accumulation

Yongzan Wei、Yi Wang、Fuchu Hu、Wei Wang、Changbin Wei、Bingqiang Xu、Liqin Liu、Huayang Li、Can Wang、Hongna Zhang、Zhenchang Liang、Jianghui Xie

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State Key Laboratory of Biological Breeding of Tropical Crops,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China

Key Laboratory of Tropical Fruit Biology (Ministry of Agriculture and Rural Affairs),South Subtropical Crops Research Institute,Chinese Academy of Tropical Agricultural Sciences,Zhanjiang 524091,China

Sanya Research Academy,Chinese Academy of Tropical Agricultural Sciences,Sanya 572019,China

Beijing Key Laboratory of Grape Sciences and Enology,CAS Key Laboratory of Plant Resources,Institute of Botany,Chinese Academy of Sciences,Beijing 100093,China

Key Laboratory of Genetic Resources Evaluation and Utilization of Tropical Fruits and Vegetables (Co-construction by Ministry and Province),Ministry of Agriculture and Rural Affairs/Institute of Tropical Fruit Trees,Hainan Academy of Agricultural Sciences,Haikou 571100,China

Haikou Experimental Station,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China

Sanya Institute of Breeding and Multiplication/School of Tropical Agriculture and Forestry,Hainan University,Haikou 570228,China

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Clausena lansium genome evolution methyltransferase activity alkaloid biosynthesis coumarin accumulation

2024

10.1016/j.jia.2024.07.043

农业科学学报(英文)
中国农业科学院农业信息研究所

农业科学学报(英文)

CSTPCD
影响因子：0.576
ISSN：2095-3119
年,卷(期)：2024.23(10)