Effect of Jingfang Huangjing liquor on psoriasis-like mice
The therapeutic effect of the traditional Chinese medicine Huangjing liquor on psoriasis-like mice was studied.A psoriasis-like mouse model was constructed with 5％imiquimod(IMQ)cream,the effect of blank control group,model group,methotrexate group,low-dose Huangjing liquor group(5 ml/(kg·d)),medium-dose group(10 ml/(kg·d)),high-dose group(20 ml/(kg·d)),Huangjing liquor group(20 ml/(kg·d)),and water extract group(20 ml/(kg·d))on the levels of diseased skin lesions,inflammatory response and oxidative stress in psoriatic mice was investigated.The results showed that compared to the model group,effective alleviation of decreased body weight and splenomegaly was observed in the low,medium,and high-dose Huangjing liquor groups.Hematoxylin-eosin(HE)staining results demonstrated that the epidermal layer thickness of mice in the Huangjing liquor group significantly decreased,the degree of inflammatory cell infiltration in the dermis was milder,and there was improvement in the affected skin area,with a more pronounced effect at higher doses.The expression levels of IL-17A were highly significantly reduced in the low,medium,and high-dose Huangjing liquor groups(P＜0.01).The malonaldehyde content was highly significantly decreased(P＜0.01),and the catalase(CAT)content was significantly increased(P＜0.05)in all Huangjing liquor groups.The superoxide dismutase(SOD)activity was highly significantly increased(P＜0.01)in the high-dose Huangjing liquor group,while there was no significant change in activity in the low and medium-dose groups(P＞0.05).In conclusion,the high-dose Huangjing liquor group(20 ml/(kg·d))had a significant improvement effect on the symptoms of psoriasis-like mice induced by imiquimod.
万方数据
维普
