Batch fermentation kinetics of hypoglycemic active substances produced by Inonotus obliquus
In this study,the mycelium of Inonotus obliquus was cultured by submerged fermentation,the change rules between different initial glucose addition and mycelium growth,substrate consumption and hypoglycemic metabolites formation with culture time were studied in the metabolites with hypoglycemic activity production by I.obliquus fermentation,and the batch fermentation kinetics model was established.The results showed that the mycelium growth and hypoglycemic metabolites formation of I.obliquus were the optimal using 30 g/L glucose as carbon source.Compared with the initial condition of 20 g/L glucose as carbon source,the biomass was increased by 10.87%,the maximum growth rate was increased by 11.9%,the maximum specific growth rate was increased by 19.3%,and the maximum formation rate and maximum specific formation rate of metabolites were increased by 27.9%and 50.57%,respectively.Under the conditions,the inhibition rate of fermentation broth on α-glucosidase reached the highest of 89.82%,and the maximum substrate consumption rate was higher than that of other groups.
万方数据
维普
