摘要
真菌发酵可以使中药化学成分发生糖基化、羟基化、甲基化等多种化学反应,并产生丰富的次生代谢产物,具有效率高、条件温和、选择性强、不污染环境、反应类型多等优势,但发酵过程的稳定性和可控性一直是个难题.该文概括了中药发酵技术及常用于发酵中药的真菌,综述了中药化学成分(黄酮、生物碱、甾体、萜类、醌类、苯丙素)的转化机制,并总结了真菌发酵中药常见菌种在中药成分转化中的应用,为后续合理利用真菌进行中药成分研究与开发提供参考依据.
Abstract
Fungal fermentation can cause a variety of chemical reactions such as glycosylation,hydroxylation and methylation of the chemical compo-nents of traditional Chinese medicine,and produce abundant secondary metabolites.Fungal fermentation has the advantages of high efficiency,mild conditions,strong selectivity,no pollution to the environment,and multiple reaction types,but the stability and controllability of the fermentation pro-cess have always been a problem.In this paper,the fermentation technology of traditional Chinese medicine and fungi commonly used in the fermen-tation were summarized,the transformation mechanism of traditional Chinese medicine chemical components(flavonoids,alkaloids,steroids,ter-penoids,quinones,phenylpropanoids)was reviewed,and the application of common fungi in the transformation of traditional Chinese medicine com-ponents was summarized,so as to provide references for the subsequent research and development of traditional Chinese medicine components with the rational use of fungi.
基金项目
江西中医药大学研究生创新专项资金项目(JZYC22S61)
国家自然科学基金项目(81260621)
NETL
NSTL
万方数据