Objective To investigate the of latent syphilis among inpatients in general hospital. Methods During the period of Jan. 2007 to Oct. 2011 in our hospital, the clinical data 278 cases latent syphilis were retrospectively analyzed. Results Latent syphilis patients had significant differences in gender, with sex ratio of 1: 1.46 (male to female). Incidence rate of latent syphilis was 67.2% in the group of 31 ~ 60 years old and 26.6% in the group of 41 ~ 50 year old. There was highest Incidence rate of latent syphilis among female patients in the 31 ~ 40year old age group with 16. 2% and 12. 2% among male patients in the 41 ~ 50 age group. Latent syphilis patients mainly distribute in department of obstetrics and gynecology, orthopedics, general surgery and etc. Department of obstetrics and gyneeology should be severely monitored for syphilis with the highest detection rate of 25.2%. Conclusion Infection of latent syphilis increased quickly in recent years, especially among women. The predilection age of latent syphilis, younger in female than male, latent syphilis distributes widely in inpatients characterized by epidemiology. Inpatients of high risk should be screened for syphilis routinely to prevent leaking syphilis and to control spread of latent syphilis.