运用限制性立方样条分析老年HIV/AIDS患者CD4+T淋巴细胞计数与死亡的剂量-反应关系
Analysis of the Dose-Response Relationship Between CD4+T Lymphocyte Counts and Mortality in Elderly HIV/AIDS Patients Based on Restricted Cubic Spline Model
孙若寒 1金艳涛 2康秋佳 1马彦民 3马秀霞 2袁君 2许前磊 1郭会军2
作者信息
- 1. 河南中医药大学第一附属医院,河南郑州 450000;河南中医药大学,河南郑州 450046
- 2. 河南中医药大学第一附属医院,河南郑州 450000
- 3. 河南省疾病预防控制中心,河南郑州 450016
- 折叠
摘要
目的 探讨老年HIV/AIDS患者CD4+T淋巴细胞计数对死亡的剂量-反应关系.方法 使用"艾滋病综合防治信息系统"收集河南某地区2003年10月—2021年10月期间60岁HIV/AIDS患者信息,对满足纳入标准的HIV/AIDS患者随访10年或者至2021年10月或者死亡.采用寿命表法计算老年HIV/AIDS患者死亡密度、Kaplan-Meier法绘制生存曲线,限制性立方样条(RCS)模型分析CD4+T淋巴细胞计数对死亡的剂量-反应关系.结果 纳入分析1 670例60岁HIV/AIDS患者,共随访10 816人年,死亡586例,死亡密度为5.40/100人年.RCS模型结果显示,老年HIV/AIDS患者CD4+T淋巴细胞计数与死亡之间呈现非线性关系,CD4+T淋巴细胞较低时患者死亡风险较大,CD4+T淋巴细胞＞200个/μL时,死亡风险曲线趋于平缓.结论 CD4+T淋巴细胞计数＜200个/μL是老年HIV/AIDS患者死亡风险升高的重要节点,建议密切关注此类人群,提高老年HIV/AIDS患者生活质量,降低其病死率.
Abstract
Objective To explore the dose-response relationship between CD4+T lymphocytes counts and mortality in elderly HIV/AIDS patients.Methods Information of 60-year-old HIV/AIDS patients in a certain area of Henan Province from October 2003 to October 2021 was collected based on the"Integrated AIDS Prevention and Control Information System".HIV/AIDS patients meeting the inclusion criteria were followed up for 10 years or until October 2021 or died.The death density of elderly HIV/AIDS patients was calculated by life table method,the survival curve was plotted by Kaplan-Meier method,and the dose-response relationship between CD4+T lymphocyte counts and mortality was analyzed by restricted cubic spline(RCS)model.Results A total of 1 670 60-year-old HIV/AIDS patients were included in the analysis.A total of 10 816 person-years were followed up,and 586 cases died,with a death density of 5.40/100 person-years.The RCS model indicated a nonlinear relationship between CD4+T lymphocyte counts and mortality,with a higher risk of death when CD4+T lymphocyte counts were low.When CD4+T lymphocyte count was＞200 cells/μL,the death risk curve tended to be flat.Conclusion CD4+T lymphocyte count＜200 cells/μL is an important knot for the increased risk of mortality in elderly HIV/AIDS patients.It is recommended to closely monitor this population to improve the quality of life and reduce mortality rates among elderly HIV/AIDS patients.
关键词
CD4+T淋巴细胞计数/HIV/AIDS/限制性立方样条/剂量-反应关系Key words
CD4+T lymphocyte counts/HIV/AIDS/Restricted cubic splines/The dose-response relationship引用本文复制引用
出版年
2025
NETL
NSTL
万方数据