Analysis of the Dose-Response Relationship Between CD4+T Lymphocyte Counts and Mortality in Elderly HIV/AIDS Patients Based on Restricted Cubic Spline Model
Objective To explore the dose-response relationship between CD4+T lymphocytes counts and mortality in elderly HIV/AIDS patients.Methods Information of 60-year-old HIV/AIDS patients in a certain area of Henan Province from October 2003 to October 2021 was collected based on the"Integrated AIDS Prevention and Control Information System".HIV/AIDS patients meeting the inclusion criteria were followed up for 10 years or until October 2021 or died.The death density of elderly HIV/AIDS patients was calculated by life table method,the survival curve was plotted by Kaplan-Meier method,and the dose-response relationship between CD4+T lymphocyte counts and mortality was analyzed by restricted cubic spline(RCS)model.Results A total of 1 670 60-year-old HIV/AIDS patients were included in the analysis.A total of 10 816 person-years were followed up,and 586 cases died,with a death density of 5.40/100 person-years.The RCS model indicated a nonlinear relationship between CD4+T lymphocyte counts and mortality,with a higher risk of death when CD4+T lymphocyte counts were low.When CD4+T lymphocyte count was＞200 cells/μL,the death risk curve tended to be flat.Conclusion CD4+T lymphocyte count＜200 cells/μL is an important knot for the increased risk of mortality in elderly HIV/AIDS patients.It is recommended to closely monitor this population to improve the quality of life and reduce mortality rates among elderly HIV/AIDS patients.
NETL
NSTL
万方数据
