Role of TWEAK/Fn14-NF-κB-VEGF Signaling Pathway in Angiogenesis
Angiogenesis is a complex prococess,which is involved in the occurrence and development of many normal physiology and diseases,and is regulated by a variety of cytokines,signaling pathways and genes.The combination of tumor necrosis factor-like weak apoptosis inducible factor(TWEAK)and receptor fibroblast growth factor-inducible factor 14(Fn14)can regulate cell proliferation,cell differentiation and angiogenesis.With the development of research,TWEAK/Fn14 provides a new direction for the occurrence and treatment of many diseases.This article reviews the relationship and role of TWEAK/Fn14-NF-κB-VEGF signaling pathway in angiogenesis.
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