Mechanical itch is a sensation caused by gentle tactile stimuli(pressure,touch,or vibration)on the skin.Alloknesis refers to the pathological phenomenon where itch receptors become hypersensitive under chronic pathological conditions,leading to persistent and severe itching even with mild tactile stimuli.This pathological condition can initiate a vicious cycle of itching,scratching,and inflammation,significantly impacting the physical and mental health as well as the quality of life of patients.As the first-discovered mechanosensitive ion channels in mammals,the Piezo protein family can convert external mechanical stimuli into electrochemical signals to affect cell behavior,and then participate in the regulation of various life activities in the body.This article summarizes the research progress of the Piezo protein family involved in the formation of mechanical itch in recent years and provides insights and foundations for the treatment of alloknesis.
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