The characteristics of bacillus and its application in leather industry were introduced.The changes of bacillus' performances after genetic modification were described.The genetic modification could improve thermal stability and acid-alkali tolerance of the enzymes produced by bacillus,and also it would change substrate specificity,thus improving the effect of enzymes on leather making.The application prospect of enzymes in leather making process was put forward.Effective and controllable processes can be established by further research,thereby extending the application of bacillus in leather making process.