Determination of Dimethyl Fumarate in Leather Using Liquid-Liquid Microextraction with Deep Eutectic Solvents
An analytical method for the determination of dimethyl fumarate in leather was developed based on liq-uid-liquid microextraction with deep eutectic solvent ( DES) combined with gas chromatography and mass spectrome-try.Seven different eutectic solvents were synthesized.The effects of the types of eutectic solvent and dispersant,the content of acetonitrile in the extraction solution,the temperature and time of ultrasonic extraction and the volume of extractant on the extraction efficiency were studied.The extraction efficiency was the highest when water/acetonitrile mixture ( volume ratio 10︰1) was used as the solvent,and the DES composed of choline chloride and hexafluoroiso-propanol ( molar ratio 1 ︰ 3) was used as the extractant.Under the optimized conditions,the linear relationship is good in the concentration range of 0.005～2.0 mg/L,the quantitative detection limit is 0.025 mg/kg,and the stand-ard recovery is in the range of 81.5％ to 105.7％ under the three different concentration levels of 0.1 mg/L,0.5 mg/L and 2.0 mg/L.The relative standard deviation is between 3.2％ and 8.5％.The pretreatment with water and green solvent reduces the amount of organic reagent,the operation process is simple and rapid,and it is suitable for the determination of dimethyl fumarate in leather.
deep eutectic solventliquid-liquid microextractiondimethyl fumaratehexafluoroisopropanolgas chromatography and mass spectrometry
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