The effects of dynamic regulation of nutrient solution concentration and depth on the growth and quality of lettuce were studied under deep flow technique(DFT)mode with semi-heading lettuce variety'Flanders'as the test material.The results showed that with the increase of nutrient solution concentration,both growth indicators and quality indicators such as soluble protein,soluble sugar,and VC initially improved before declining.The best results were achieved with a nutrient concentration increment of 0.36 mS·cm-1 every eight days,which significantly enhanced leaf length,leaf width,chlorophyll-a content,total chlorophyll content,root vitality,both the fresh and dry weight of aboveground and underground parts,soluble protein content,soluble sugar content,and VC content compared to other treatments.The fresh weight of aboveground parts increasing by 22.3%to 57.9%.Additionally,the study identified significant variations in plant growth and quality based on the depth of the nutrient solution.The plants grown at liquid levels of 12-16 cm exhibited superior growth and quality outcomes,while those grown at a 4 cm liquid level showed poorer performance.