In order to investigate the effect of wine lees-based organic-inorganic compound fertilizer on pod pepper in the karst mountainous area of Guizhou province,a two-year field experiment was conducted to study the effects of conventional chemical fertilizer(CF,N-P2O5-K2O=15-15-15),organic-inorganic compound fertilizer 1(OIF1,N-P2O5-K2O=12-5-10,organic matter≥30%),and organic-inorganic compound fertilizer 2(OIF2,N-P2O5-K2O=8-3-6,organic matter≥40%)on the yield,quality,nutrient accumulation,fertilizer utilization and soil fertility of pod pepper in Guizhou.Compared with the CF treatment,the application of OIF1 and OIF2 increased the fresh and dry pepper yields of pod pepper by 5.86%-21.93%and 3.34%-16.36%,respectively.Meanwhile,the reducing sugar content of OIF1 and OIF2 treatments was significantly increased by 41.05%and 31.88%in 2023,respectively.And the nitrate content of OIF1 and OIF2 treatments in 2023 was significantly reduced by 26.41%and 32.24%compared to CF treatment,respectively.In addition,the application of OIF1 and OIF2 also played a positive impact in promoting the nutrient accumulation,increasing the fertilizer utilization and improving the soil fertility level.On the whole,the application of wine lees-based organic-inorganic compound fertilizer had a positive effect on the production capacity and fertilizer effect of pod pepper,which can be used as an effective technical way to improve the quality and increase the yield of pod pepper in mountainous areas of Guizhou.