Neuronal Response to Reward and Luminance in Macaque LIP During Saccadic Choice

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外文摘要：Recent work in decision neuroscience suggests that visual saliency can interact with reward-based choice,and the lateral intraparietal cortex(LIP)is implicated in this process.In this study,we recorded from LIP neurons while monkeys performed a two alternative choice task in which the reward and luminance associated with each offer were varied independently.We discovered that the animal's choice was dictated by the reward amount while the luminance had a marginal effect.In the LIP,neuronal activity corresponded well with the animal's choice pattern,in that a majority of reward-modulated neurons encoded the reward amount in the neuron's preferred hemifield with a positive slope.In contrast,compared to their responses to low luminance,an approximately equal proportion of luminance-sensitive neurons responded to high luminance with increased or decreased activity,leading to a much weaker population-level response.Meanwhile,in the non-preferred hemifield,the strength of encoding for reward amount and luminance was positively correlated,suggesting the integration of these two factors in the LIP.Moreover,neurons encoding reward and luminance were homogeneously distributed along the anterior-posterior axis of the LIP.Overall,our study pro-vides further evidence supporting the neural instantiation of a priority map in the LIP in reward-based decisions.

外文关键词：

RewardLuminanceAttentionPriority mapSaccadic choiceLateral intraparietal cortex

作者：

Ziqi Wu、Aihua Chen、Xinying Cai

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作者单位：

Key Laboratory of Brain Functional Genomics(Ministry of Education),East China Normal University(ECNU),Shanghai 200062,China

NYU-ECNU Institute of Brain,Cognitive Science at NYU Shanghai,Shanghai 200062,China

New York University(NYU)Shanghai,Shanghai 200122,China

Key Laboratory of Brain Functional Genomics(Ministry of Education),School of Psychology and Cognitive Science,ECNU,Shanghai 200062,China

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基金：

National Science and Technology Innovation 2030 Major ProgramShanghai Municipal Science and Technology Major ProjectProgram of Introducing Talents of Discipline to UniversitiesProgram of Introducing Talents of Discipline to UniversitiesNYU Shanghai Boost Fund

项目编号：

2021ZD0203700/2021ZD02037022018SHZDZX05Ministry of Education of ChinaBase B16018

出版年：

2023

DOI：

10.1007/s12264-022-00948-0

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

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影响因子：0.741

ISSN：1673-7067

年,卷(期)：2023.39(1)

参考文献量30