神经科学通报(英文版)2023,Vol.39Issue(1) :29-40.DOI:10.1007/s12264-022-00889-8

Contextual Fear Learning and Extinction in the Primary Visual Cortex of Mice

Xiaoke Xie Shangyue Gong Ning Sun Jiazhu Zhu Xiaobin Xu Yongxian Xu Xiaojing Li Zhenhong Du Xuanting Liu Jianmin Zhang Wei Gong Ke Si
神经科学通报(英文版)2023,Vol.39Issue(1) :29-40.DOI:10.1007/s12264-022-00889-8

Contextual Fear Learning and Extinction in the Primary Visual Cortex of Mice

Xiaoke Xie 1Shangyue Gong 2Ning Sun 3Jiazhu Zhu 4Xiaobin Xu 3Yongxian Xu 3Xiaojing Li 3Zhenhong Du 4Xuanting Liu 3Jianmin Zhang 2Wei Gong 5Ke Si6
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作者信息

  • 1. Department of Psychiatry,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310012,China;College of Biomedical Engineering and Instrument Science,Zhejiang University,Hangzhou 310012,China;Intelligent Optics & Photonics Research Center,Jiaxing Research Institute,Zhejiang University,Jiaxing 314001,China
  • 2. Department of Neurosurgery of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310012,China
  • 3. MOE Frontier Science Center for Brain Science & Brain-Machine Integration,NHC and CAMS Key Laboratory of Medical Neurobiology,School of Brain Science and Brain Medicine,Zhejiang University,Hangzhou 310012,China
  • 4. Intelligent Optics & Photonics Research Center,Jiaxing Research Institute,Zhejiang University,Jiaxing 314001,China;State Key Laboratory of Modern Optical Instrumentation.College of Optical Science and Engineering,Zhejiang University,Hangzhou 310012,China
  • 5. Department of Neurosurgery of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310012,China;MOE Frontier Science Center for Brain Science & Brain-Machine Integration,NHC and CAMS Key Laboratory of Medical Neurobiology,School of Brain Science and Brain Medicine,Zhejiang University,Hangzhou 310012,China
  • 6. Department of Psychiatry,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310012,China;College of Biomedical Engineering and Instrument Science,Zhejiang University,Hangzhou 310012,China;Intelligent Optics & Photonics Research Center,Jiaxing Research Institute,Zhejiang University,Jiaxing 314001,China;MOE Frontier Science Center for Brain Science & Brain-Machine Integration,NHC and CAMS Key Laboratory of Medical Neurobiology,School of Brain Science and Brain Medicine,Zhejiang Univ
  • 折叠

Abstract

Fear memory contextualization is critical for selecting adaptive behavior to survive.Contextual fear con-ditioning(CFC)is a classical model for elucidating related underlying neuronal circuits.The primary visual cortex(V1)is the primary cortical region for contextual visual inputs,but its role in CFC is poorly understood.Here,our experi-ments demonstrated that bilateral inactivation of V1 in mice impaired CFC retrieval,and both CFC learning and extinc-tion increased the turnover rate of axonal boutons in V1.The frequency of neuronal Ca2+activity decreased after CFC learning,while CFC extinction reversed the decrease and raised it to the naïve level.Contrary to control mice,the frequency of neuronal Ca2+activity increased after CFC learning in microglia-depleted mice and was maintained after CFC extinction,indicating that microglial depletion alters CFC learning and the frequency response pattern of extinction-induced Ca2+activity.These findings reveal a critical role of microglia in neocortical information pro-cessing in V1,and suggest potential approaches for cellular-based manipulation of acquired fear memory.

Key words

Contextual fear conditioning/Calcium imaging/Primary visual cortex/Cortical plasticity/Microglial depletion/Learning and memory

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基金项目

National Natural Science Foundation of China(61735016)

Natural Science Foundation of Zhejiang Province(LR20F050002)

Key R&D Program of Zhejiang Province(2020C03009)

Key R&D Program of Zhejiang Province(2021C03001)

Zhejiang Leading Innovation and Entrepreneurship Team(202099144)

CAMS Innovation Fund for Medical Sciences(2019-I2M-5-057)

Fundamental Research Funds for the Central Universities()

出版年

2023
神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子:0.741
ISSN:1673-7067
参考文献量50
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