首页|Contextual Fear Learning and Extinction in the Primary Visual Cortex of Mice

Contextual Fear Learning and Extinction in the Primary Visual Cortex of Mice

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Fear memory contextualization is critical for selecting adaptive behavior to survive.Contextual fear con-ditioning(CFC)is a classical model for elucidating related underlying neuronal circuits.The primary visual cortex(V1)is the primary cortical region for contextual visual inputs,but its role in CFC is poorly understood.Here,our experi-ments demonstrated that bilateral inactivation of V1 in mice impaired CFC retrieval,and both CFC learning and extinc-tion increased the turnover rate of axonal boutons in V1.The frequency of neuronal Ca2+activity decreased after CFC learning,while CFC extinction reversed the decrease and raised it to the naïve level.Contrary to control mice,the frequency of neuronal Ca2+activity increased after CFC learning in microglia-depleted mice and was maintained after CFC extinction,indicating that microglial depletion alters CFC learning and the frequency response pattern of extinction-induced Ca2+activity.These findings reveal a critical role of microglia in neocortical information pro-cessing in V1,and suggest potential approaches for cellular-based manipulation of acquired fear memory.

Contextual fear conditioningCalcium imagingPrimary visual cortexCortical plasticityMicroglial depletionLearning and memory

Xiaoke Xie、Shangyue Gong、Ning Sun、Jiazhu Zhu、Xiaobin Xu、Yongxian Xu、Xiaojing Li、Zhenhong Du、Xuanting Liu、Jianmin Zhang、Wei Gong、Ke Si

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Department of Psychiatry,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310012,China

College of Biomedical Engineering and Instrument Science,Zhejiang University,Hangzhou 310012,China

Intelligent Optics & Photonics Research Center,Jiaxing Research Institute,Zhejiang University,Jiaxing 314001,China

Department of Neurosurgery of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310012,China

MOE Frontier Science Center for Brain Science & Brain-Machine Integration,NHC and CAMS Key Laboratory of Medical Neurobiology,School of Brain Science and Brain Medicine,Zhejiang University,Hangzhou 310012,China

State Key Laboratory of Modern Optical Instrumentation.College of Optical Science and Engineering,Zhejiang University,Hangzhou 310012,China

MOE Frontier Science Center for Brain Science & Brain-Machine Integration,NHC and CAMS Key Laboratory of Medical Neurobiology,School of Brain Science and Brain Medicine,Zhejiang Univ

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National Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang ProvinceKey R&D Program of Zhejiang ProvinceKey R&D Program of Zhejiang ProvinceZhejiang Leading Innovation and Entrepreneurship TeamCAMS Innovation Fund for Medical SciencesFundamental Research Funds for the Central Universities

61735016LR20F0500022020C030092021C030012020991442019-I2M-5-057

2023

10.1007/s12264-022-00889-8

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

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影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(1)
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