首页|Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation

Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation

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The optimal protocol for neuromodulation by transcranial direct current stimulation(tDCS)remains unclear.Using the rotarod paradigm,we found that mouse motor learning was enhanced by anodal tDCS(3.2 mA/cm2)during but not before or after the performance of a task.Dual-task experiments showed that motor learning enhance-ment was specific to the task accompanied by anodal tDCS.Studies using a mouse model of stroke induced by middle cerebral artery occlusion showed that concurrent anodal tDCS restored motor learning capability in a task-specific manner.Transcranial in vivo Ca2+imaging further showed that anodal tDCS elevated and cathodal tDCS suppressed neuronal activity in the primary motor cortex(M1).Anodal tDCS specifically promoted the activity of task-related M1 neurons during task performance,suggesting that elevated Hebbian synaptic potentiation in task-activated circuits accounts for the motor learning enhancement.Thus,appli-cation of tDCS concurrent with the targeted behavioral dysfunction could be an effective approach to treating brain disorders.

Motor learningtDCS effectNeural mechanism of tDCSNeuronal excitabilityStroke model mouse

Ying Wang、Jixian Wang、Qing-Fang Zhang、Ke-Wei Xiao、Liang Wang、Qing-Ping Yu、Qing Xie、Mu-Ming Poo、Yunqing Wen

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Institute of Neuroscience,State Key Laboratory of Neuroscience,Key Laboratory of Primate Neurobiology,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China

University of Chinese Academy of Sciences,Beijing 100049,China

School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Lingang Laboratory,Shanghai 201210,China

Department of Rehabilitation Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

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Strategic Priority Research Program of the Chinese Academy of SciencesShanghai Municipal Science and Technology Major ProjectShanghai Key Basic Research ProjectLingang LabLingang LabShanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch

XDB320701002018SHZDZX0518JC1410100LG202106-04-03LG202105-01-07JCYJ-SHFY-2022-010

2023

10.1007/s12264-022-00901-1

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

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影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(1)
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