神经科学通报(英文版)2023,Vol.39Issue(1) :69-82.DOI:10.1007/s12264-022-00901-1

Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation

Ying Wang Jixian Wang Qing-Fang Zhang Ke-Wei Xiao Liang Wang Qing-Ping Yu Qing Xie Mu-Ming Poo Yunqing Wen
神经科学通报(英文版)2023,Vol.39Issue(1) :69-82.DOI:10.1007/s12264-022-00901-1

Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation

Ying Wang 1Jixian Wang 2Qing-Fang Zhang 3Ke-Wei Xiao 3Liang Wang 3Qing-Ping Yu 3Qing Xie 2Mu-Ming Poo 1Yunqing Wen3
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作者信息

  • 1. Institute of Neuroscience,State Key Laboratory of Neuroscience,Key Laboratory of Primate Neurobiology,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China;University of Chinese Academy of Sciences,Beijing 100049,China;School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China;Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Lingang Laboratory,Shanghai 201210,China
  • 2. Department of Rehabilitation Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
  • 3. Institute of Neuroscience,State Key Laboratory of Neuroscience,Key Laboratory of Primate Neurobiology,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China
  • 折叠

Abstract

The optimal protocol for neuromodulation by transcranial direct current stimulation(tDCS)remains unclear.Using the rotarod paradigm,we found that mouse motor learning was enhanced by anodal tDCS(3.2 mA/cm2)during but not before or after the performance of a task.Dual-task experiments showed that motor learning enhance-ment was specific to the task accompanied by anodal tDCS.Studies using a mouse model of stroke induced by middle cerebral artery occlusion showed that concurrent anodal tDCS restored motor learning capability in a task-specific manner.Transcranial in vivo Ca2+imaging further showed that anodal tDCS elevated and cathodal tDCS suppressed neuronal activity in the primary motor cortex(M1).Anodal tDCS specifically promoted the activity of task-related M1 neurons during task performance,suggesting that elevated Hebbian synaptic potentiation in task-activated circuits accounts for the motor learning enhancement.Thus,appli-cation of tDCS concurrent with the targeted behavioral dysfunction could be an effective approach to treating brain disorders.

Key words

Motor learning/tDCS effect/Neural mechanism of tDCS/Neuronal excitability/Stroke model mouse

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基金项目

Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32070100)

Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)

Shanghai Key Basic Research Project(18JC1410100)

Lingang Lab(LG202106-04-03)

Lingang Lab(LG202105-01-07)

Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(JCYJ-SHFY-2022-010)

出版年

2023
神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

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影响因子:0.741
ISSN:1673-7067
参考文献量71
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