Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation

Ying Wang ¹Jixian Wang ²Qing-Fang Zhang ³Ke-Wei Xiao ³Liang Wang ³Qing-Ping Yu ³Qing Xie ²Mu-Ming Poo ¹Yunqing Wen³

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作者信息

1. Institute of Neuroscience,State Key Laboratory of Neuroscience,Key Laboratory of Primate Neurobiology,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China;University of Chinese Academy of Sciences,Beijing 100049,China;School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China;Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Lingang Laboratory,Shanghai 201210,China
2. Department of Rehabilitation Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
3. Institute of Neuroscience,State Key Laboratory of Neuroscience,Key Laboratory of Primate Neurobiology,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China
折叠

Abstract

The optimal protocol for neuromodulation by transcranial direct current stimulation(tDCS)remains unclear.Using the rotarod paradigm,we found that mouse motor learning was enhanced by anodal tDCS(3.2 mA/cm2)during but not before or after the performance of a task.Dual-task experiments showed that motor learning enhance-ment was specific to the task accompanied by anodal tDCS.Studies using a mouse model of stroke induced by middle cerebral artery occlusion showed that concurrent anodal tDCS restored motor learning capability in a task-specific manner.Transcranial in vivo Ca2+imaging further showed that anodal tDCS elevated and cathodal tDCS suppressed neuronal activity in the primary motor cortex(M1).Anodal tDCS specifically promoted the activity of task-related M1 neurons during task performance,suggesting that elevated Hebbian synaptic potentiation in task-activated circuits accounts for the motor learning enhancement.Thus,appli-cation of tDCS concurrent with the targeted behavioral dysfunction could be an effective approach to treating brain disorders.

Key words

Motor learning/tDCS effect/Neural mechanism of tDCS/Neuronal excitability/Stroke model mouse

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基金项目

Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32070100)

Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)

Shanghai Key Basic Research Project(18JC1410100)

Lingang Lab(LG202106-04-03)

Lingang Lab(LG202105-01-07)

Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(JCYJ-SHFY-2022-010)

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量71

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