Abstract
Neurodegenerative diseases(NDs)have become a significant threat to an aging human society.Numerous studies have been conducted in the past decades to clarify their pathologic mechanisms and search for reliable bio-markers.Magnetic resonance imaging(MRI)is a powerful tool for investigating structural and functional brain altera-tions in NDs.With the advantages of being non-invasive and non-radioactive,it has been frequently used in both animal research and large-scale clinical investigations.MRI may serve as a bridge connecting micro-and macro-level analysis and promoting bench-to-bed translational research.Nevertheless,due to the abundance and complexity of MRI techniques,exploiting their potential is not always straight-forward.This review aims to briefly introduce research pro-gress in clinical imaging studies and discuss possible strate-gies for applying MRI in translational ND research.
基金项目
This review was supported by the National Natural Science Foundation of China(81971577)
This review was supported by the National Natural Science Foundation of China(81771820)
Natural Science Foundation of Zhejiang Province(LSZ19H180001)
13th Fiveyear Plan for National Key Research and Development Program of China(2016YFC1306600)
维普
万方数据