首页|Somatostatin-Positive Neurons in the Rostral Zona Incerta Modulate Innate Fear-Induced Defensive Response in Mice

Somatostatin-Positive Neurons in the Rostral Zona Incerta Modulate Innate Fear-Induced Defensive Response in Mice

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Defensive behaviors induced by innate fear or Pavlovian fear conditioning are crucial for animals to avoid threats and ensure survival.The zona incerta(ZI)has been demonstrated to play important roles in fear learning and fear memory,as well as modulating auditory-induced innate defensive behavior.However,whether the neuronal subtypes in the ZI and specific circuits can mediate the innate fear response is largely unknown.Here,we found that somato-statin(SST)-positive neurons in the rostral ZI of mice were activated by a visual innate fear stimulus.Optogenetic inhi-bition of SST-positive neurons in the rostral ZI resulted in reduced flight responses to an overhead looming stimulus.Optogenetic activation of SST-positive neurons in the rostral ZI induced fear-like defensive behavior including increased immobility and bradycardia.In addition,we demonstrated that manipulation of the GABAergic projections from SST-positive neurons in the rostral ZI to the downstream nucleus reuniens(Re)mediated fear-like defensive behavior.Ret-rograde trans-synaptic tracing also revealed looming stim-ulus-activated neurons in the superior colliculus(SC)that projected to the Re-projecting SST-positive neurons in the rostral ZI(SC-ZIrSST-Re pathway).Together,our study elu-cidates the function of SST-positive neurons in the rostral ZI and the SC-ZIrSST-Re tri-synaptic circuit in mediating the innate fear response.

Innate fearZona incertaSomatostatin-positive neuronsLooming stimulusDefensive behavior

Shan Lin、Meng-Yue Zhu、Meng-Yu Tang、Mi Wang、Xiao-Dan Yu、Yi Zhu、Shi-Ze Xie、Dan Yang、Jiadong Chen、Xiao-Ming Li

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Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China

NHC and CAMS Key Laboratory of Medical Neurobiology,MOE Frontier Science Center for Brain Research and Brain-Machine Integration,School of Brain Science and Brian Medicine,Zhejiang University,Hangzhou 310058,China

Center for Brain Science and Brain-Inspired Intelligence,Research Units for Emotion and Emotion Disorders,Chinese Academy of Medical Sciences,China/

Research Assistant Shuangshuang Liu from the Core Facilities of Zhejiang University School of MedicineCore Facilities of Zhejiang University Institute of NeuroscienceScience and Technology Innovation 2030—Major Project of Brain Science and Brainlike ResearchScience and Technology Innovation 2030—Major Project of Brain Science and Brainlike ResearchKey-Area Research and Development Program of Guangdong ProvinceKey-Area Research and Development Program of Guangdong ProvinceMajor Program of the National Natural Science Foundation of ChinaMajor Program of the National Natural Science Foundation of ChinaCAMS Innovation Fund for Medical SciencesMinistry of Science and TechnologyNational Natural Science Foundation of ChinaFundamental Research Funds for the Central UniversitiesZhejiang Provincial Natural Science FoundationYoung Scientist Program of the National Natural Science Foundation of China

2021ZD02027002021ZD02027022019B0303350012018B03033400182090030820900312019-I2M-5-0572019YFA0110103818708982021FZZX001-37LR18H09000282001135

2023

10.1007/s12264-022-00958-y

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(2)
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