首页|Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions

Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions

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Aging is a major risk factor for many human diseases,including cognitive impairment,which affects a large population of the elderly.In the past few decades,our understanding of the molecular and cellular mechanisms underlying the changes associated with aging and age-related diseases has expanded greatly,shedding light on the potential role of these changes in cognitive impairment.In this article,we review recent advances in understanding of the mechanisms underlying brain aging under normal and pathological conditions,compare their similarities and dif-ferences,discuss the causative and adaptive mechanisms of brain aging,and finally attempt to find some rules to guide us on how to promote healthy aging and prevent age-related diseases.

Healthy agingPathological agingCognitive impairment

Menglong Jin、Shi-Qing Cai

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Institute of Neuroscience and State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China

University of Chinese Academy of Sciences,Beijing 100049,China

National Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaStrategic Priority Research Program of the Chinese Academy of SciencesShanghai Municipal science and Technology Major ProjectInnovative Research Team of Highlevel Local Universities in Shanghai

2018YFC20004003192502291949206XDB320201002018SHZDZX05SHSMU-ZDCX20212501

2023

10.1007/s12264-022-00969-9

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(2)
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