首页|Chemogenetic and Optogenetic Manipulations of Microglia in Chronic Pain

Chemogenetic and Optogenetic Manipulations of Microglia in Chronic Pain

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Chronic pain relief remains an unmet medical need.Current research points to a substantial contribution of glia-neuron interaction in its pathogenesis.Particularly,microglia play a crucial role in the development of chronic pain.To better understand the microglial contribution to chronic pain,specific regional and temporal manipulations of microglia are necessary.Recently,two new approaches have emerged that meet these demands.Chemogenetic tools allow the expression of designer receptors exclusively activated by designer drugs(DREADDs)specifically in microglia.Similarly,optogenetic tools allow for microglial manipulation via the activation of artificially expressed,light-sensitive proteins.Chemo-and optogenetic manipu-lations of microglia in vivo are powerful in interrogating microglial function in chronic pain.This review summarizes these emerging tools in studying the role of microglia in chronic pain and highlights their potential applications in microglia-related neurological disorders.

Chronic painMicrogliaOptogeneticsChemogeneticsDREADDsReaChR

Sebastian Parusel、Min-Hee Yi、Christine L.Hunt、Long-Jun Wu

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Department of Neurology,Mayo Clinic,Rochester,MN 55905,USA

Faculty of Psychology and Neuroscience,Maastricht University,Maastricht MD,6200,The Netherlands

Department of Pain Medicine,Mayo Clinic,Jacksonville,FL 32224,USA

Department of Neuroscience,Mayo Clinic,Jacksonville,FL 32224,USA

Department of Immunology,Mayo Clinic,Rochester,MN 55905,USA

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National Institutes of HealthNational Institutes of Health

R01NS088627R01NS110825

2023

10.1007/s12264-022-00937-3

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(3)
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