Abstract
Glioma is the most common and lethal intrinsic primary tumor of the brain.Its controversial origins may contribute to its heterogeneity,creating challenges and dif-ficulties in the development of therapies.Among the compo-nents constituting tumors,glioma stem cells are highly plas-tic subpopulations that are thought to be the site of tumor initiation.Neural stem cells/progenitor cells and oligoden-drocyte progenitor cells are possible lineage groups populat-ing the bulk of the tumor,in which gene mutations related to cell-cycle or metabolic enzymes dramatically affect this transformation.Novel approaches have revealed the tumor-promoting properties of distinct tumor cell states,glial,neural,and immune cell populations in the tumor microen-vironment.Communication between tumor cells and other normal cells manipulate tumor progression and influence sensitivity to therapy.Here,we discuss the heterogeneity and relevant functions of tumor cell state,microglia,monocyte-derived macrophages,and neurons in glioma,highlight-ing their bilateral effects on tumors.Finally,we describe potential therapeutic approaches and targets beyond standard treatments.
基金项目
National Key Research and Development Program of China(2020YFA0804200)
National Natural Science Foundation of China(82073166)
National Natural Science Foundation of China(82273203)
Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)
Program for Professors of Special Appointment(Eastern Scholar)at the Shanghai Institutions of Higher Learning(SSF151005)
Student Scientific Research Program(Fuqing Scholar)of Shanghai Medical College,Fudan University(FQXZ202117C)
NETL
NSTL
维普
万方数据