首页|Astrocytes in Chronic Pain:Cellular and Molecular Mechanisms

Astrocytes in Chronic Pain:Cellular and Molecular Mechanisms

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Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of ther-apies.Astrocytes are the most abundant glial cells in the central nervous system and play important roles in different pathological conditions,including chronic pain.Astrocytes regulate nociceptive synaptic transmission and network function via neuron-glia and glia-glia interactions to exag-gerate pain signals under chronic pain conditions.It is also becoming clear that astrocytes play active roles in brain regions important for the emotional and memory-related aspects of chronic pain.Therefore,this review presents our current understanding of the roles of astrocytes in chronic pain,how they regulate nociceptive responses,and their cel-lular and molecular mechanisms of action.

AstrocyteMicrogliaNeuron-glia interactionSpinal cordChronic pain

Huan-Jun Lu、Yong-Jing Gao

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Institute of Pain Medicine and Special Environmental Medicine,Co-innovation Center of Neuroregeneration,Nantong University,Nantong 226019,China

Ministry of Science and Technology of China Brain Initiative GrantNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of the Higher Education Institutions of Jiangsu Province

2022ZD0204702320300483210080621KJB310010

2023

10.1007/s12264-022-00961-3

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(3)
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