Abstract
Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of ther-apies.Astrocytes are the most abundant glial cells in the central nervous system and play important roles in different pathological conditions,including chronic pain.Astrocytes regulate nociceptive synaptic transmission and network function via neuron-glia and glia-glia interactions to exag-gerate pain signals under chronic pain conditions.It is also becoming clear that astrocytes play active roles in brain regions important for the emotional and memory-related aspects of chronic pain.Therefore,this review presents our current understanding of the roles of astrocytes in chronic pain,how they regulate nociceptive responses,and their cel-lular and molecular mechanisms of action.
基金项目
Ministry of Science and Technology of China Brain Initiative Grant(2022ZD0204702)
National Natural Science Foundation of China(32030048)
National Natural Science Foundation of China(32100806)
Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(21KJB310010)
NETL
NSTL
维普
万方数据