首页|Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways

Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways

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Myelin-forming oligodendrocytes in the central nervous system(CNS)and Schwann cells in the peripheral nervous system(PNS)are essential for structural and func-tional homeostasis of nervous tissue.Albeit with certain similarities,the regulation of CNS and PNS myelination is executed differently.Recent advances highlight the coordi-nated regulation of oligodendrocyte myelination by amino-acid sensing and growth factor signaling pathways.In this review,we discuss novel insights into the understanding of differential regulation of oligodendrocyte and Schwann cell biology in CNS and PNS myelination,with particular focus on the roles of growth factor-stimulated RHEB-mTORC1 and GATOR2-mediated amino-acid sensing/signaling path-ways.We also discuss recent progress on the metabolic regu-lation of oligodendrocytes and Schwann cells and the impact of their dysfunction on neuronal function and disease.

OligodendrocyteSchwann cellmyelinationRHEBmTORC1MIOSGATOR2mitochondrialactate

Zhiwen Yang、Zongyan Yu、Bo Xiao

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Shenzhen Key Laboratory of Gene Regulation and Systems Biology,Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen 518000,China

Shenzhen Innovation Committee of Science and TechnologyShenzhen Key Laboratory of Gene Regulation and Systems BiologyNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions

ZDSYS20200811144002008201919398431970773315300422021SHIBS0002

2023

10.1007/s12264-022-00967-x

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(3)
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