Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways

Zhiwen Yang ¹Zongyan Yu ¹Bo Xiao¹

扫码查看

作者信息

1. Shenzhen Key Laboratory of Gene Regulation and Systems Biology,Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen 518000,China
折叠

Abstract

Myelin-forming oligodendrocytes in the central nervous system(CNS)and Schwann cells in the peripheral nervous system(PNS)are essential for structural and func-tional homeostasis of nervous tissue.Albeit with certain similarities,the regulation of CNS and PNS myelination is executed differently.Recent advances highlight the coordi-nated regulation of oligodendrocyte myelination by amino-acid sensing and growth factor signaling pathways.In this review,we discuss novel insights into the understanding of differential regulation of oligodendrocyte and Schwann cell biology in CNS and PNS myelination,with particular focus on the roles of growth factor-stimulated RHEB-mTORC1 and GATOR2-mediated amino-acid sensing/signaling path-ways.We also discuss recent progress on the metabolic regu-lation of oligodendrocytes and Schwann cells and the impact of their dysfunction on neuronal function and disease.

Key words

Oligodendrocyte/Schwann cell/myelination/RHEB/mTORC1/MIOS/GATOR2/mitochondria/lactate

引用本文复制引用

基金项目

Shenzhen Innovation Committee of Science and Technology(ZDSYS20200811144002008)

Shenzhen Key Laboratory of Gene Regulation and Systems Biology(2019193984)

National Natural Science Foundation of China(31970773)

National Natural Science Foundation of China(31530042)

Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2021SHIBS0002)

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量115

段落导航