Abstract
Multiple sclerosis(MS)is regarded as a chronic inflammatory disease that leads to demyelination and even-tually to neurodegeneration.Activation of innate immune cells and other inflammatory cells in the brain and spinal cord of people with MS has been well described.However,with the innovation of technology in glial cell research,we have a deep understanding of the mechanisms of glial cells connecting inflammation and neurodegeneration in MS.In this review,we focus on the role of glial cells,including microglia,astrocytes,and oligodendrocytes,in the patho-genesis of MS.We mainly focus on the connection between glial cells and immune cells in the process of axonal damage and demyelinating neuron loss.
NETL
NSTL
维普
万方数据