Abstract
The accumulation of pathological α-synuclein(α-syn)in the central nervous system and the progressive loss of dopaminergic neurons in the substantia nigra pars compacta are the neuropathological features of Parkinson's disease(PD).Recently,the findings of prion-like transmis-sion of α-syn pathology have expanded our understanding of the region-specific distribution of α-syn in PD patients.Accumulating evidence suggests that α-syn aggregates are released from neurons and endocytosed by glial cells,which contributes to the clearance of α-syn.However,the activa-tion of glial cells by α-syn species produces pro-inflamma-tory factors that decrease the uptake of α-syn aggregates by glial cells and promote the transmission of α-syn between neurons,which promotes the spread of α-syn pathology.In this article,we provide an overview of current knowledge on the role of glia and α-syn pathology in PD pathogenesis,highlighting the relationships between glial responses and the spread of α-syn pathology.
基金项目
National Natural Science Foundation of China(32271039)
National Natural Science Foundation of China(32070970)
National Natural Science Foundation of China(31871023)
Joint Program RFBR-BRICS(17-54-80006)
Priority Academic Program Development of Jiangsu Higher Education Institutions()
NETL
NSTL
万方数据