首页|Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders

Novel Microglia-based Therapeutic Approaches to Neurodegenerative Disorders

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As prominent immune cells in the central nerv-ous system,microglia constantly monitor the environment and provide neuronal protection,which are important func-tions for maintaining brain homeostasis.In the diseased brain,microglia are crucial mediators of neuroinflamma-tion that regulates a broad spectrum of cellular responses.In this review,we summarize current knowledge on the multifunctional contributions of microglia to homeostasis and their involvement in neurodegeneration.We further pro-vide a comprehensive overview of therapeutic interventions targeting microglia in neurodegenerative diseases.Notably,we propose microglial depletion and subsequent repopula-tion as promising replacement therapy.Although microglial replacement therapy is still in its infancy,it will likely be a trend in the development of treatments for neurodegenerative diseases due to its versatility and selectivity.

MicrogliaNeuroinflammationMultifunctionMicroglial replacementNeurodegeneration

Lijuan Zhang、Yafei Wang、Taohui Liu、Ying Mao、Bo Peng

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Department of Neurosurgery,Huashan Hospital,Institute for Translational Brain Research,State Key Laboratory of Medical Neurobiology,MOE Frontiers Center for Brain Science,Fudan University,Shanghai 200040,China

Co-innovation Center of Neuroregeneration,Nantong University,Nantong 226001,China

Jiachen Zhu and Fang Lei(Fudan University)for their excellent laboratory management.This review was supported by STI2030-Major PNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai Academic Technology Research Leader ProgramShanghai Pilot Program for Basic ResearchShanghai Municipal Science and Technology Major ProjectInnovative Research Team of High-Level Local Universities in ShanghaiShanghai Municipal Science and Technology Major ProjectZJ LabChina Postdoctoral Science Foundation

2022ZD0204700319220273217095821XD142040021TQ0142018SHZDZX012021M690687

2023

10.1007/s12264-022-01013-6

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(3)
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