Abstract
The concept of the glial-vascular unit(GVU)was raised recently to emphasize the close associations between brain cells and cerebral vessels,and their coordi-nated reactions to diverse neurological insults from a"glio-centric"view.GVU is a multicellular structure composed of glial cells,perivascular cells,and perivascular space.Each component is closely linked,collectively forming the GVU.The central roles of glial and perivascular cells and their multi-level interconnections in the GVU under normal conditions and in central nervous system(CNS)disorders have not been elucidated in detail.Here,we comprehen-sively review the intensive interactions between glial cells and perivascular cells in the niche of perivascular space,which take part in the modulation of cerebral blood flow and angiogenesis,formation of the blood-brain barrier,and clearance of neurotoxic wastes.Next,we discuss dysfunc-tions of the GVU in various neurological diseases,including ischemic stroke,spinal cord injury,Alzheimer's disease,and major depression disorder.In addition,we highlight the pos-sible therapies targeting the GVU,which may have potential clinical applications.
基金项目
Ministry of science and Technology China Brain Initiative Grant(2022ZD0204704)
National Natural Science Foundation of China(81974180)
Young Excellent Medical Scholarship of Hubei Province(2020 LJRC011)
NETL
NSTL
维普
万方数据