首页|Roles of NG2 Glia in Cerebral Small Vessel Disease
Roles of NG2 Glia in Cerebral Small Vessel Disease
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Cerebral small vessel disease(CSVD)is one of the most prevalent pathologic processes affecting 5％ of peo-ple over 50 years of age and contributing to 45％ of dementia cases.Increasing evidence has demonstrated the pathologi-cal roles of chronic hypoperfusion,impaired cerebral vas-cular reactivity,and leakage of the blood-brain barrier in CSVD.However,the pathogenesis of CSVD remains elusive thus far,and no radical treatment has been developed.NG2 glia,also known as oligodendrocyte precursor cells,are the fourth type of glial cell in addition to astrocytes,microglia,and oligodendrocytes in the mammalian central nervous system.Many novel functions for NG2 glia in physiological and pathological states have recently been revealed.In this review,we discuss the role of NG2 glia in CSVD and the underlying mechanisms.
NG2 gliaOligodendrocyte precursor cellCerebral small vessel diseaseWhite matter injury
Yixi He、Zhenghao Li、Xiaoyu Shi、Jing Ding、Xin Wang
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Department of Neurology,Zhongshan Hospital,Fudan University,Shanghai 200032,China
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Institutes of Brain Science,Fudan University,Shanghai 200032,China
Institute of Neuroscience,MOE Key Laboratory of Molecular Neurobiology,NMU,Shanghai 200433,China
National Natural Science Foundation of ChinaChina Postdoctoral Science Foundation
NETL
NSTL
万方数据
维普
