首页|The Structure and Function of Glial Networks:Beyond the Neuronal Connections

The Structure and Function of Glial Networks:Beyond the Neuronal Connections

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Glial cells,consisting of astrocytes,oligoden-drocyte lineage cells,and microglia,account for＞50％of the total number of cells in the mammalian brain.They play key roles in the modulation of various brain activities under physiological and pathological conditions.Although the typical morphological features and characteristic func-tions of these cells are well described,the organization of interconnections of the different glial cell populations and their impact on the healthy and diseased brain is not com-pletely understood.Understanding these processes remains a profound challenge.Accumulating evidence suggests that glial cells can form highly complex interconnections with each other.The astroglial network has been well described.Oligodendrocytes and microglia may also contribute to the formation of glial networks under various circumstances.In this review,we discuss the structure and function of glial networks and their pathological relevance to central nervous system diseases.We also highlight opportunities for future research on the glial connectome.

Glia networkGap junctionCalcium couplingCNS diseases

Hai-Rong Peng、Yu-Kai Zhang、Jia-Wei Zhou

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Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China

School of Future Technology,University of Chinese Academy of Sciences,Beijing 100049,China

Ministry of Science and Technology of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaStrategic Priority Research Program of the Chinese Academy of ScienceShanghai Municipal Science and Technology Major ProjectKey Realm R&D Program of Guangdong Province

2020YFC200280032230049U1801681XDB320201002018SHZDZX052018B030337001

2023

10.1007/s12264-022-00992-w

神经科学通报(英文版)
中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD
影响因子：0.741
ISSN：1673-7067
年,卷(期)：2023.39(3)
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