首页|Interactions Between Astrocytes and Oligodendroglia in Myelin Development and Related Brain Diseases
Interactions Between Astrocytes and Oligodendroglia in Myelin Development and Related Brain Diseases
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Astrocytes(ASTs)and oligodendroglial lin-eage cells(OLGs)are major macroglial cells in the cen-tral nervous system.ASTs communicate with each other through connexin(Cx)and Cx-based network structures,both of which allow for quick transport of nutrients and signals.Moreover,ASTs interact with OLGs through con-nexin(Cx)-mediated networks to modulate various physi-ological processes in the brain.In this article,following a brief description of the infrastructural basis of the glial net-works and exocrine factors by which ASTs and OLGs may crosstalk,we focus on recapitulating how the interactions between these two types of glial cells modulate myelina-tion,and how the AST-OLG interactions are involved in protecting the integrity of the blood-brain barrier(BBB)and regulating synaptogenesis and neural activity.Recent studies further suggest that AST-OLG interactions are associated with myelin-related diseases,such as multiple sclerosis.A better understanding of the regulatory mechanisms underly-ing AST-OLG interactions may inspire the development of novel therapeutic strategies for related brain diseases.
School of Medicine,Chongqing University,Chongqing 400030,China
Department of Histology and Embryology,Chongqing Key Laboratory of Neurobiology,Brain and Intelligence Research Key Laboratory of Chongqing Education Commission,Third Military Medical University,Chongqing 400038,China
Ministry of Science and Technology of ChinaNational Natural Science Foundation of China
NETL
NSTL
万方数据
维普
