Influence of Recent Trial History on Interval Timing

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外文摘要：Interval timing is involved in a variety of cog-nitive behaviors such as associative learning and decision-making.While it has been shown that time estimation is adaptive to the temporal context,it remains unclear how interval timing behavior is influenced by recent trial history.Here we found that,in mice trained to perform a licking-based interval timing task,a decrease of inter-reinforce-ment interval in the previous trial rapidly shifted the time of anticipatory licking earlier.Optogenetic inactivation of the anterior lateral motor cortex(ALM),but not the medial prefrontal cortex,for a short time before reward delivery caused a decrease in the peak time of anticipatory licking in the next trial.Electrophysiological recordings from the ALM showed that the response profiles preceded by short and long inter-reinforcement intervals exhibited task-engagement-dependent temporal scaling.Thus,interval timing is adap-tive to recent experience of the temporal interval,and ALM activity during time estimation reflects recent experience of interval.

外文关键词：

Peak-interval timing procedureTemporal contextTrial historySecondary motor cortexTemporal scaling

作者：

Taorong Xie、Can Huang、Yijie Zhang、Jing Liu、Haishan Yao

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作者单位：

Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China

University of Chinese Academy of Sciences,Beijing 100049,China

Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Shanghai 201210,China

基金：

National Science and Technology Innovation 2030 Major Program of ChinaNational Natural science Foundation of ChinaNational Natural science Foundation of ChinaLingang LabShanghai Municipal Science and Technology Major ProjectStrategic Priority Research Program of the Chinese Academy of Sciences

项目编号：

2021ZD0203700/2021ZD02037033177115132171030LG202104-01-032018SHZDZX05XDB32010200

出版年：

2023

DOI：

10.1007/s12264-022-00954-2

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

年,卷(期)：2023.39(4)

参考文献量96