Abstract
Interval timing is involved in a variety of cog-nitive behaviors such as associative learning and decision-making.While it has been shown that time estimation is adaptive to the temporal context,it remains unclear how interval timing behavior is influenced by recent trial history.Here we found that,in mice trained to perform a licking-based interval timing task,a decrease of inter-reinforce-ment interval in the previous trial rapidly shifted the time of anticipatory licking earlier.Optogenetic inactivation of the anterior lateral motor cortex(ALM),but not the medial prefrontal cortex,for a short time before reward delivery caused a decrease in the peak time of anticipatory licking in the next trial.Electrophysiological recordings from the ALM showed that the response profiles preceded by short and long inter-reinforcement intervals exhibited task-engagement-dependent temporal scaling.Thus,interval timing is adap-tive to recent experience of the temporal interval,and ALM activity during time estimation reflects recent experience of interval.
基金项目
National Science and Technology Innovation 2030 Major Program of China(2021ZD0203700/2021ZD0203703)
National Natural science Foundation of China(31771151)
National Natural science Foundation of China(32171030)
Lingang Lab(LG202104-01-03)
Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)
Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32010200)
维普
万方数据