首页|Functional Autapses Form in Striatal Parvalbumin Interneurons but not Medium Spiny Projection Neurons
Functional Autapses Form in Striatal Parvalbumin Interneurons but not Medium Spiny Projection Neurons
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Autapses selectively form in specific cell types in many brain regions.Previous studies have also found puta-tive autapses in principal spiny projection neurons(SPNs)in the striatum.However,it remains unclear whether these neurons indeed form physiologically functional autapses.We applied whole-cell recording in striatal slices and iden-tified autaptic cells by the occurrence of prolonged asyn-chronous release(AR)of neurotransmitters after bursts of high-frequency action potentials(APs).Surprisingly,we found no autaptic AR in SPNs,even in the presence of Sr2+.However,robust autaptic AR was recorded in parvalbumin(PV)-expressing neurons.The autaptic responses were medi-ated by GABAA receptors and their strength was dependent on AP frequency and number.Further computer simulations suggest that autapses regulate spiking activity in PV cells by providing self-inhibition and thus shape network oscilla-tions.Together,our results indicate that PV neurons,but not SPNs,form functional autapses,which may play important roles in striatal functions.
Xuan Wang、Zhenfeng Shu、Quansheng He、Xiaowen Zhang、Luozheng Li、Xiaoxue Zhang、Liang Li、Yujie Xiao、Bo Peng、Feifan Guo、Da-Hui Wang、Yousheng Shu
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School of Systems Science and State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing 100875,China
Department of Neurosurgery,Jinshan Hospital,State Key Laboratory of Medical Neurobiology,MOE Frontiers Center for Brain Science,Institute for Translational Brain Research,Fudan University,Shanghai 200032,China
Section of Infection and Immunity,Herman Ostrow School of Dentistry,University of Southern California,Los Angeles,CA 90089,USA
National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of China
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