Control of Emotion and Wakefulness by Neurotensinergic Neurons in the Parabrachial Nucleus

Jingwen Chen ¹Noam Gannot ²Xingyu Li ³Rongrong Zhu ⁴Chao Zhang ⁴Peng Li⁵

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作者信息

1. Fundamental Research Center,Shanghai Yangzhi Rehabilitation Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 201619,China;Life Sciences Institute,University of Michigan,Ann Arbor,MI 48109,USA
2. Life Sciences Institute,University of Michigan,Ann Arbor,MI 48109,USA;Department of Biologic and Materials Sciences,School of Dentistry,University of Michigan,Ann Arbor,MI 48109,USA
3. Life Sciences Institute,University of Michigan,Ann Arbor,MI 48109,USA
4. Fundamental Research Center,Shanghai Yangzhi Rehabilitation Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 201619,China
5. Life Sciences Institute,University of Michigan,Ann Arbor,MI 48109,USA;Department of Biologic and Materials Sciences,School of Dentistry,University of Michigan,Ann Arbor,MI 48109,USA;Department of Molecular and Integrative Physiology,School of Medicine,University of Michigan,Ann Arbor,MI 48109,USA
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Abstract

The parabrachial nucleus(PBN)integrates inter-oceptive and exteroceptive information to control various behavioral and physiological processes including breath-ing,emotion,and sleep/wake regulation through the neu-ral circuits that connect to the forebrain and the brainstem.However,the precise identity and function of distinct PBN subpopulations are still largely unknown.Here,we leveraged molecular characterization,retrograde tracing,optogenetics,chemogenetics,and electrocortical recording approaches to identify a small subpopulation of neurotensin-expressing neurons in the PBN that largely project to the emotional control regions in the forebrain,rather than the medulla.Their activation induces freezing and anxiety-like behaviors,which in turn result in tachypnea.In addition,optogenetic and chemogenetic manipulations of these neurons revealed their function in promoting wakefulness and maintaining sleep architecture.We propose that these neurons com-prise a PBN subpopulation with specific gene expression,connectivity,and function,which play essential roles in behavioral and physiological regulation.

Key words

Parabrachial nucleus/Neurotensin/Anxiety/Sleep/Wakefulness/Breathing/Neural circuit/Freezing/Medulla

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基金项目

University of Michigan startup funds()

NIH(R01 AT011652)

NIH(R01 HL156989)

出版年

2023

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

参考文献量52

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