Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice

扫码查看

原文链接

万方数据
维普

外文摘要：Methcathinone(MCAT)belongs to the designer drugs called synthetic cathinones,which are abused world-wide for recreational purposes.It has strong stimulant effects,including enhanced euphoria,sensation,alertness,and empa-thy.However,little is known about how MCAT modulates neuronal activity in vivo.Here,we evaluated the effect of MCAT on neuronal activity with a series of functional approaches.C-Fos immunostaining showed that MCAT increased the number of activated neurons by 6-fold,espe-cially in sensory and motor cortices,striatum,and midbrain motor nuclei.In vivo single-unit recording and two-photon Ca2+imaging revealed that a large proportion of neurons increased spiking activity upon MCAT administration.Nota-bly,MCAT induced a strong de-correlation of population activity and increased trial-to-trial reliability,specifically during a natural movie stimulus.It improved the information-processing efficiency by enhancing the single-neuron cod-ing capacity,suggesting a cortical network mechanism of the enhanced perception produced by psychoactive stimulants.

外文关键词：

MethcathinoneSynthetic psychoactive substanceIn vivo single-unit recordingCa2+imagingNucleus accumbensVisual cortex

作者：

Jun Zhou、Wen Deng、Chen Chen、Junya Kang、Xiaodan Yang、Zhaojuan Dou、Jiancheng Wu、Quancong Li、Man Jiang、Man Liang、Yunyun Han

展开 >

作者单位：

Department of Neurobiology,School of Basic Medicine and Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Institute for Brain Research,Collaborative Innovation Center for Brain Science,Huazhong University of Science and Technology,Wuhan 430030,China

Department of Forensic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Department of Physiology,School of Basic Medicine and Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Key Laboratory of Forensic Toxicology,Ministry of Public Security,Beijing 100192,China

展开 >

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaJunior Thousand Talents Program of China,Fundamental Research Funds for the Central UniversitiesJunior Thousand Talents Program of China,Fundamental Research Funds for the Central UniversitiesKey Laboratory of Forensic Toxicology,Ministry of Public Security of China Beijing Municipal Public Security BureauKey Laboratory of Forensic Toxicology,Ministry of Public Security of China Beijing Municipal Public Security Bureau

项目编号：

3187108931871028HUST:2172019kfyXKJC077HUST:2172019kfyRCPY0642020FTDWFX022019FTDWFX06

出版年：

2023

DOI：

10.1007/s12264-022-00965-z

神经科学通报(英文版)

中国科学院上海生命科学研究院

神经科学通报(英文版)

CSTPCDCSCD

影响因子：0.741

ISSN：1673-7067

年,卷(期)：2023.39(4)

参考文献量53