Abstract
Methcathinone(MCAT)belongs to the designer drugs called synthetic cathinones,which are abused world-wide for recreational purposes.It has strong stimulant effects,including enhanced euphoria,sensation,alertness,and empa-thy.However,little is known about how MCAT modulates neuronal activity in vivo.Here,we evaluated the effect of MCAT on neuronal activity with a series of functional approaches.C-Fos immunostaining showed that MCAT increased the number of activated neurons by 6-fold,espe-cially in sensory and motor cortices,striatum,and midbrain motor nuclei.In vivo single-unit recording and two-photon Ca2+imaging revealed that a large proportion of neurons increased spiking activity upon MCAT administration.Nota-bly,MCAT induced a strong de-correlation of population activity and increased trial-to-trial reliability,specifically during a natural movie stimulus.It improved the information-processing efficiency by enhancing the single-neuron cod-ing capacity,suggesting a cortical network mechanism of the enhanced perception produced by psychoactive stimulants.
基金项目
National Natural Science Foundation of China(31871089)
National Natural Science Foundation of China(31871028)
Junior Thousand Talents Program of China,Fundamental Research Funds for the Central Universities(HUST:2172019kfyXKJC077)
Junior Thousand Talents Program of China,Fundamental Research Funds for the Central Universities(HUST:2172019kfyRCPY064)
Key Laboratory of Forensic Toxicology,Ministry of Public Security of China Beijing Municipal Public Security Bureau(2020FTDWFX02)
Key Laboratory of Forensic Toxicology,Ministry of Public Security of China Beijing Municipal Public Security Bureau(2019FTDWFX06)
维普
万方数据